A definite role for treatment with activated protein C in sepsis? Standard use is premature
نویسندگان
چکیده
منابع مشابه
Activated protein C and sepsis
Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established. APC has anticoagulant, anti-inflammatory, antiapoptotic, and profibrinolytic properties, but it is not clear through which of these mechanisms APC exerts its benefit in severe sepsis. Focus has recently turned to th...
متن کاملActivated protein C and sepsis.
Protein C is a plasma protease that when activated plays a central role in modulating the function of the vascular endothelium and its interface with the innate immune system. A recombinant form of human activated protein C (APC), drotrecogin alfa (activated), has shown efficacy in a number of preclinical models of thrombosis and ischemia and reduces mortality in patients that have a high risk ...
متن کاملProtein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
INTRODUCTION Drotrecogin alfa (activated; DrotAA) treatment, a 96-hour infusion, reduces 28-day mortality in severe sepsis to approximately 25%. The question remains whether a longer infusion or higher dose could increase rate of survival. The goal of this study was to identify a dependable, sensitive measure with which to monitor disease progression and response in patients during DrotAA treat...
متن کاملRecombinant human activated protein C for severe sepsis.
BACKGROUND Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa activated produced dose-dependent reductions in the levels of markers of coagulation and inflammation in patients with severe sepsis. In this phase 3 trial, we assessed whether treatment with drotrecogin al...
متن کاملImmediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6
Background: The purpose of this study was to determine the relationship between early onset sepsis and increased levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in cord plasma. Methods: A prospective study was conducted in 141 premature infants delivered with gestational ages of 26-35 weeks. IL-6 and CPR were measured by enzyme-linked immunoassay in the cord plasma of the neonates. ...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2003
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2003.00486.x